Research projects

Identification of molecular aberrations related to cisplatin resistance in testicular germ cell tumors

Molecular monitoring of patients with advanced testicular germ cell tumors and its potential impact in clinical practice

Circulating biomarkers as novel prognostic and predictive factors in testicular germ cell tumors.

Clinical projects

Long-term outcomes of testicular tumor patients management

MORAY: Molecular profiling and precision targeted therapy for refractory testicular germ cell tumors – a prospective non-randomized multicenter phase II trial

Prof. Tomas Buchler, MD, PhD, Dept. of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague

Ass. Prof. Katerina Komrskova, MSc, PhD, Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences

Prof. Leendert Looijenga, PhD, Princess Máxima Center, Utrecht

Ass. Prof. Michal Chovanec, MD, PhD, II. Dept. of Oncology, Medical Faculty, Comenius University, National Oncology Institute, Bratislava

Qasemi M, Sur VP, Simonik O, Postlerova P, Skrobanek P, Hradec T, Boublikova L, Zamecnik L, Buchler T, Neuzil J, Komrskova K. Sperm mitochondria dysfunction in response to testicular cancer. Eur J Clin Invest, 2023 Dec 8:e14146

DOI: 10.1111/eci.14146

Boublikova L, Skvarova Kramarzova K, Zwyrtkova M, Bakardjieva-Mihaylova V, Stuchly J, Rosova B, Kolostova K, Sonsky J, Kindlova E, Zachoval R, Buchler T, Trka J. The clinical value of circulating free tumor DNA in testicular germ cell tumor patients. Urol Oncol. 2022, 18: S1078-1439(22)00150-8.

DOI: 10.1016/j.urolonc.2022.04.021

Bakardjieva-Mihaylova, V., Kramarzova, K.S., Slamova, M., Svaton, M., Rejlova, K., Zaliova, M., Dobiasova, A., Fiser, K., Stuchly, J., Grega, M., Rosova, B., Zachoval, R., Klezl, P., Eis, V., Kindlova, E., Buchler, T., Trka, J., Boublikova, L. Molecular basis of cisplatin resistance in testicular germ cell tumors. Cancers, 2019, 11 (9), art. no. 1316

DOI: 10.3390/cancers11091316

Racková, M., Bakardjieva-Mihaylova, V., Slámová, M., Boublíková, L., Škvárová, K.K. Genome editing using the CRISPR/Cas9 system and its application in haematology [Genová editace systémem CRISPR/Cas9 a její využití v hematologii]. Transfuze a Hematologie Dnes, 2019, 25 (4): 291-299.

Bakardjieva-Mihaylova, V., Skvarova Kramarzova, K., Slamova, M., Buchler, T., Boublíkova, L. Molecular pathogenesis of testicular germ cell tumors [Molekularní patogeneze testikulárních germinalních nadoru]. Klinicka Onkologie, 2017, 30 (6): 412-419.

Boublikova, L., Bakardjieva-Mihaylova, V., Skvarova Kramarzova, K., Kuzilkova, D., Dobiasova, A., Fiser, K., Stuchly, J., Kotrova, M., Buchler, T., Dusek, P., Grega, M., Rosova, B., Vernerova, Z., Klezl, P., Pesl, M., Zachoval, R., Krolupper, M., Kubecova, M., Stahalova, V., Abrahamova, J., Babjuk, M., Kodet, R., Trka, J. Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. Cancer Letters, 2016, 376 (2): 367-376.

DOI: 10.1016/j.canlet.2016.04.016

Boublikova, L., Buchler, T., Stary, J., Abrahamova, J., Trka, J. Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application. Critical Reviews in Oncology/ Hematology, 2014, 89 (3): 366-385.

DOI: 10.1016/j.critrevonc.2013.10.001

Buchler, T., Kubankova, P., Boublikova, L., Donatova, Z., Foldyna, M., Kanakova, J., Kordikova, D., Kupec, M., Nepomucka, J., Vorsilkova, E., Abrahamova, J. Detection of second malignancies during long-term follow-up of testicular cancer survivors. Cancer, 2011, 117 (18): 4212-4218.

DOI: 10.1002/cncr.26039